Recent advances in the chemistry of imine-based multicomponent reactions (MCRs)

Recent advances in multicomponent reactions for diversity-oriented synthesis.

Interest in multicomponent reactions (MCRs) has surged during the past two decades as interest in the efficient synthesis of small molecule libraries has gained prominence. MCRs fill an important niche in library synthesis by providing direct access to library compounds and by serving as starting points for Diversity-Oriented Synthesis (DOS). Recent advances in the area of MCR chemistry have in...

Multicomponent reactions in nucleoside chemistry

This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized ...

Application of Green Chemistry in Synthesis of Functionalized Thiopyran viaOne-pot Multicomponent Reactions in Water

An efficient synthesis of 2H-thiopyran-3,4-dicarboxylate derivatives via one-pot reactions between acetylenic esters, arylisothiocyanates and enaminones in water is described.The advantages of this work were: (1) the reaction was performed under neutral and more important in water as the solvent. (2) No catalyst was required for this reaction. (3) The simplicity of the present procedure made it...

Recent advances in spin chemistry*

The great success in controlling chemical reactivity by spin manipulation was achieved in the last decade, and many remarkable spin and magnetic phenomena have been discovered. Among those discoveries, the most chemically important highlights are magnetic isotope effect, spin catalysis, and single-spin tunneling spectroscopy. This paper summarizes recent advances in these new and hot areas of m...

application of green chemistry in synthesis of functionalized thiopyran viaone-pot multicomponent reactions in water